Auto-Mag® Carboxyl NanoBeads (C-30)

Highlights

• Surface carboxyl groups enable easy and efficient covalent coupling to biomolecules using standard carbodiimide chemistry.
• Low nonspecific binding and excellent sensitivity provide greater detection accuracy and reliability.
• Rapid magnetic response and excellent physical stability enable fast separation while maintaining bead integrity.
• Compatibility with automated detection workflows enhances efficiency, consistency, and reproducibility.

Auto-Mag® Carboxyl Nanobeads (C-30) are superparamagnetic nanobeads with a hydrophilic, carboxyl-functionalized surface. Surface carboxyl groups (–COOH) can be activated using EDC or EDAC chemistry to form stable covalent amide bonds with primary amines (–NH₂), enabling efficient coupling and immobilization of antibodies, antigens, proteins, amine-modified nucleic acids, and other ligands. With a high specific surface area, uniform particle size, narrow size distribution, and specialized surface coating, Auto-Mag® Carboxyl Nanobeads (C-30)  provide high binding capacity with minimal nonspecific binding to proteins and nucleic acids. Their dense structure enables rapid and efficient magnetic separation. Once conjugated, the beads are suitable for a broad range of research and diagnostic applications, including IVD, CLIA, immunoprecipitation (IP), cell sorting and capture, affinity separation, and other immunoassays applications.

Application

Auto-Mag® Carboxyl NanoBeads (C-30) are designed for developing biomolecule-conjugated magnetic beads with broad applications in research and diagnostics.

• Immunoassay
• Immunoprecipitation
• Nucleic acid hybridization
• hybridization
• Western blot
• Cell separation

Workflow of Protein Conjugation to Carboxyl NanoBeads

(EDC/EDAC-Medisted Amide Bond Formation)

Data & References

Auto-Mag® Carboxyl NanoBeads (C-30) Binding Capacity